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Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors

  • Read more about Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors

Lines, K. E., Stevenson, M., Filippakopoulos, P., Müller, S., Lockstone, H. E., Wright, B., … Thakker, R. V. (2017). Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors. Oncogenesis, 6(5), e332.

Protein destabilization and loss of protein-protein interaction are fundamental mechanisms in cblA-type methylmalonic aciduria

  • Read more about Protein destabilization and loss of protein-protein interaction are fundamental mechanisms in cblA-type methylmalonic aciduria

Plessl, T., Bürer, C., Lutz, S., Yue, W., Baumgartner, M., Froese, D. (2017). Protein destabilization and loss of protein-protein interaction are fundamental mechanisms in cblA-type methylmalonic aciduria. Human Mutation, 38(8), 988-1001.

In Vivo Biotinylation of Antigens in E. coli

  • Read more about In Vivo Biotinylation of Antigens in E. coli

Gräslund, S., Savitsky, P., Müller-Knapp, S. (2017). In Vivo Biotinylation of Antigens in E. coli. Methods In Molecular Biology, 1586, 337-344.

N- and C-Terminal Truncations to Enhance Protein Solubility and Crystallization: Predicting Protein Domain Boundaries with Bioinformatics Tools

  • Read more about N- and C-Terminal Truncations to Enhance Protein Solubility and Crystallization: Predicting Protein Domain Boundaries with Bioinformatics Tools

Cooper, C. D. O., Marsden, B. D., (2017). N- and C-Terminal Truncations to Enhance Protein Solubility and Crystallization: Predicting Protein Domain Boundaries with Bioinformatics Tools. Methods In Molecular Biology, 1586, 11-31.

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

  • Read more about The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

Kitevski-LeBlanc, J., Fradet-Turcotte, A., Kukic, P., Wilson, M. D., Portella, G., Yuwen, T., … Kay, L. E. (2017). The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage. eLife, 6, e23872.

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

  • Read more about Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

Bouché, L., Christ, C. D., Siegel, S., Fernández-Montalván, A. E., Holton, S. J., Fedorov, O., … Haendler, B. (2017). Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. Journal of Medicinal Chemistry, 60(9), 4002–4022.

Molecular basis for the methylation specificity of ATXR5 for histone H3

  • Read more about Molecular basis for the methylation specificity of ATXR5 for histone H3

Bergamin, E., Sarvan, S., Malette, J., Eram, M. S., Yeung, S., Mongeon, V., … Couture, J.-F. (2017). Molecular basis for the methylation specificity of ATXR5 for histone H3. Nucleic Acids Research, 45(11), 6375–6387.

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain

  • Read more about Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain

Denny, R., Flick, A., Coe, J., Langille, J., Basak, A., Liu, S., ... Chekler, E. L. P. (2017). Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain. Journal Of Medicinal Chemistry, 60(13), 5349-5363.

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites

  • Read more about Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites

Pearce, N. M., Bradley, A. R., Krojer, T., Marsden, B. D., Deane, C. M., & von Delft, F. (2017). Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites. Structural Dynamics, 4(3), 032104.

Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

  • Read more about Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

Wang, Z., Zhang, Y., Bartual, S. G., Luo, J., Xu, T., Du, W., … Ding, K. (2017). Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. ACS Medicinal Chemistry Letters, 8(3), 327–332.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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