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Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

  • Read more about Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

Igoe, N., Bayle, E., Tallant, C., Fedorov, O., Meier, J., Savitsky, P., ... Fish, P. V. (2017). Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins. Journal Of Medicinal Chemistry, 60(16), 6998-7011.

Structure-activity relationship studies of G9a-like protein (GLP) inhibitors

  • Read more about Structure-activity relationship studies of G9a-like protein (GLP) inhibitors

Xiong, Y., Li, F., Babault, N., Wu, H., Dong, A., & Zeng, H., ... Jin, J. (2017). Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorganic & Medicinal Chemistry, 25(16), 4414-4423.

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

  • Read more about Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Couñago, R. M., Allerston, C. K., Savitsky, P., Azevedo, H., Godoi, P. H., Wells, C. I., … Gileadi, O. (2017). Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Scientific Reports, 7, 7501.

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis

  • Read more about BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis

Roberts, T. C., Etxaniz, U., Dall’Agnese, A., Wu, S.-Y., Chiang, C.-M., Brennan, P. E., … Puri, P. L. (2017). BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis. Scientific Reports, 7, 6153.

Global analysis of protein folding using massively parallel design, synthesis, and testing

  • Read more about Global analysis of protein folding using massively parallel design, synthesis, and testing

Rocklin, G. J., Chidyausiku, T. M., Goreshnik, I., Ford, A., Houliston, S., Lemak, A., … Baker, D. (2017). Global analysis of protein folding using massively parallel design, synthesis and testing. Science (New York, N.Y.), 357(6347), 168–175.

Readers, writers and erasers of N6-methylated adenosine modification

  • Read more about Readers, writers and erasers of N6-methylated adenosine modification

Wu, B., Li, L., Huang, Y., Ma, J., & Min, J. (2017). Readers, writers and erasers of N6 -methylated adenosine modification. Current Opinion In Structural Biology, 47, 67-76.

Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment

  • Read more about Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment

Aquino, B., Couñago, R. M., Verza, N., Ferreira, L. M., Massirer, K. B., Gileadi, O., & Arruda, P. (2017). Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment. Frontiers in Plant Science, 8, 852.

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

  • Read more about Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

Chaikuad, A., Filippakopoulos, P., Marcsisin, S. R., Picaud, S., Schröder, M., Sekine, S., … Knapp, S. (2017). Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly. Structure(London, England:1993), 25(7), 1089–1099.e3.

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10

  • Read more about Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10

Zhang, W., Sartori, M., Makhnevych, T., Federowicz, K., Dong, X., Liu, L., ... Sidhu, S. S. (2017). Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10. Journal Of Molecular Biology, 429(22), 3546-3560.

A trust approach for sharing research reagents

  • Read more about A trust approach for sharing research reagents

Edwards, A., Morgan, M., Al Chawaf, A., Andrusiak, K., Charney, R., Cynader, Z., ... Zuercher, W. J. (2017). A trust approach for sharing research reagents. Science Translational Medicine, 9(392), eaai9055.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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