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Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks

  • Read more about Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks

Foley, D. J., Craven, P. G. E., Collins, P. M., Doveston, R. G., Aimon, A., Talon, R., … Nelson, A. (2017). Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks. Chemistry (Weinheim an Der Bergstrasse, Germany), 23(60), 15227–15232.

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7

  • Read more about Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7

Gerken, P. A., Wolstenhulme, J. R., Tumber, A., Hatch, S. B., Zhang, Y., Müller, S., … Smith, M. D. (2017). Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7. Angewandte Chemie (International Ed. in English), 56(49), 15555–15559.

A systematic analysis of atomic protein-ligand interactions in the PDB

  • Read more about A systematic analysis of atomic protein-ligand interactions in the PDB

Ferreira de Freitas, R., & Schapira, M. (2017). A systematic analysis of atomic protein–ligand interactions in the PDB †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00381a . Medchemcomm, 8(10), 1970–1981.

Disease Association and Druggability of WD40 Repeat Proteins

  • Read more about Disease Association and Druggability of WD40 Repeat Proteins

Song, R., Wang, Z., & Schapira, M. (2017). Disease Association and Druggability of WD40 Repeat Proteins. Journal Of Proteome Research, 16(10), 3766-3773.

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases

  • Read more about Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases

Pinkas, D. M., Sanvitale, C. E., Bufton, J. C., Sorrell, F. J., Solcan, N., Chalk, R., … Bullock, A. N. (2017). Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases. Biochemical Journal, 474(22), 3747–3761.

First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor

  • Read more about First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor

Moody, J. D., Levy, S., Mathieu, J., Xing, Y., Kim, W., Dong, C., … Ruohola-Baker, H. (2017). First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 114(38), 10125–10130.

Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities

  • Read more about Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities

Teyra, J., Huang, H., Jain, S., Guan, X., Dong, A., Liu, Y., ... Sidhu, S. S (2017). Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities. Structure, 25(10), 1598-1610.e3.

Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2

  • Read more about Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2

Zhang, H., Liu, K., Izumi, N., Huang, H., Ding, D., Ni, Z., … Min, J. (2017). Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Proceedings of the National Academy of Sciences of the United States of America, 114(47), 12483–12488.

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

  • Read more about The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

Bradley, A. R., Echalier, A., Fairhead, M., Strain-Damerell, C., Brennan, P., Bullock, A. N., … von Delft, F. (2017). The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery. Essays in Biochemistry, 61(5), 495–503.

Progress towards a public chemogenomic set for protein kinases and a call for contributions

  • Read more about Progress towards a public chemogenomic set for protein kinases and a call for contributions

Drewry, D. H., Wells, C. I., Andrews, D. M., Angell, R., Al-Ali, H., Axtman, A. D., … Willson, T. M. (2017). Progress towards a public chemogenomic set for protein kinases and a call for contributions. PLoS ONE, 12(8), e0181585.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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