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Assessing histone demethylase inhibitors in cells: lessons learned

  • Read more about Assessing histone demethylase inhibitors in cells: lessons learned

Hatch, S. B., Yapp, C., Montenegro, R. C., Savitsky, P., Gamble, V., Tumber, A., … Müller, S. (2017). Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics & Chromatin, 10, 9.

Antibody Validation by Immunoprecipitation Followed by Mass Spectrometry Analysis

  • Read more about Antibody Validation by Immunoprecipitation Followed by Mass Spectrometry Analysis

Persson, H., Preger, C., Marcon, E., Lengqvist, J., Gräslund, S. (2017). Antibody Validation by Immunoprecipitation Followed by Mass Spectrometry Analysis. Methods In Molecular Biology, 1575, 175-187.

Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family

  • Read more about Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family

Bataille, C., Brennan, M., Byrne, S., Davies, S., Durbin, M., Fedorov, O., … Wynne, G. M. (2017). Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family. Bioorganic & Medicinal Chemistry, 25(9), 2657-2665.

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

  • Read more about Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Tumber, A., Nuzzi, A., Hookway, E. S., Hatch, S. B., Velupillai, S., Johansson, C., … Brennan, P. E. (2017). Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chemical Biology, 24(3), 371–380.

Establishing a reliable framework for harnessing the creative power of the scientific crowd

  • Read more about Establishing a reliable framework for harnessing the creative power of the scientific crowd

Carter, A. J., Donner, A., Lee, W. H., Bountra, C. (2017). Establishing a reliable framework for harnessing the creative power of the scientific crowd. PLoS Biology, 15(2), e2001387.

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

  • Read more about Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Batson, J., Toop, H. D., Redondo, C., Babaei-Jadidi, R., Chaikuad, A., Wearmouth, S. F., … Morris, J. C. (2017). Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chemical Biology, 12(3), 825-832.

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

  • Read more about Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

Newman, J. A., Aitkenhead, H., Savitsky, P., Gileadi, O. (2017). Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5. Nucleic Acids Research, 45(7), 4231–4243.

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

  • Read more about Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

Wilkes, M., Madej, M. G., Kreuter, L., Rhinow, D., Heinz, V., De Sanctis, S., … Ziegler, C. (2017). Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2. Nature Structural & Molecular Biology, 24(2), 123-130.

Discovery of a PCAF Bromodomain Chemical Probe

  • Read more about Discovery of a PCAF Bromodomain Chemical Probe

Moustakim, M., Clark, P. G. K., Trulli, L., Fuentes de Arriba, A. L., Ehebauer, M. T., Chaikuad, A., … Brennan, P. E. (2017). Discovery of a PCAF Bromodomain Chemical Probe. Angewandte Chemie (International Ed. in English), 56(3), 827–831.

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

  • Read more about Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

Igoe, N., Bayle, E. D., Fedorov, O., Tallant, C., Savitsky, P., Rogers, C., … Fish, P. V. (2017). Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. Journal of Medicinal Chemistry, 60(2), 668-680.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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