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ULTRA-DD

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Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

  • Read more about Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

Babault, N., Allali-Hassani, A., Li, F., Fan, J., Yue, A., Ju, K., ... Jin, J. (2018). Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT). Journal Of Medicinal Chemistry, 61(4), 1541-1551.

Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first)

  • Read more about Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first)

Han, Z., Wu, H., Kim, S., Yang, X., Li, Q., & Huang, H., ... Zheng, Y. G. (2018). Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first). Journal Of Biological Chemistry, 293(9), 3410-3420.

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants

  • Read more about DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants

Xu, C., Liu, K., Lei, M., Yang, A., Li, Y., Hughes, T., & Min, J. (2018). DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Structure, 26(1), 85-95.e3.

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

  • Read more about Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

Kaniskan, H. Ü., Eram, M. S., Zhao, K., Szewczyk, M. M., Yang, X., Schmidt, K., … Jin, J. (2018). Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of Medicinal Chemistry, 61(3), 1204–1217.

Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2

  • Read more about Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2

Williams, E., & Bullock, A. N. (2018). Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2. Bone, 109, 251–258.

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors

  • Read more about Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors

Shadrick, W., Slavish, P., Chai, S., Waddell, B., Connelly, M., Low, J., ... Potter, P. M. (2018). Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors. Bioorganic & Medicinal Chemistry, 26(1), 25-36.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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