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Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

  • Read more about Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

Dong, Y. Y., Wang, H., Pike, A., Cochrane, S. A., Hamedzadeh, S., Wyszyński, F. J., … Carpenter, E. P. (2018). Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.Cell, 175(4), 1045–1058.e16.

Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening.

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Collins, PM., Douangamath, A., Talon, R., Dias, A., Brandao-Neto, J., Krojer, T., von Delft, F. (2018). Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening. Methods in Enzymology, 610, 251-264.

Target Identification Using Chemical Probes

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Moustakim, M., Felce, SL., Zaarour, N., Farnie, G., McCann, FE., Brennan, PE. (2018). Target Identification Using Chemical Probes. Methods in Enzymology, 610, 27-58.

A Structure-Based Approach Towards Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)

  • Read more about A Structure-Based Approach Towards Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)

Heidenreich, D., Moustakim, M., Schmidt, J., Merk, D., Brennan, PE., Fedorov, O., ... Knapp, S. (2018). Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). Journal Of Medicinal Chemistry, 61(23), 10929-10934.

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

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Vazquez-Rodriguez, S., Wright, M., Rogers, C. M., Cribbs, A. P., Velupillai, S., Philpott, M., … Brennan, P. E. (2018). Design, Synthesis and Characterization of Covalent KDM5 Inhibitors. Angewandte Chemie (International ed. in English),58(2), 515–519.

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

  • Read more about Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

Lambert, J. P., Picaud, S., Fujisawa, T., Hou, H., Savitsky, P., Uusküla-Reimand, L., … Gingras, A. C. (2019). Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.Molecular cell,73(3), 621–638.e17.

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

  • Read more about Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

Clerici, M., Faini, M., Muckenfuss, L., Aebersold, R., & Jinek, M. (2018). Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex. Nature Structural & Molecular Biology, 25(2), 135-138.

Structures of human PRC2 with its cofactors AEBP2 and JARID2

  • Read more about Structures of human PRC2 with its cofactors AEBP2 and JARID2

Kasinath, V., Faini, M., Poepsel, S., Reif, D., Feng, X., Stjepanovic, G., ... Nogales, E (2018). Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359(6378), 940-944.

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

  • Read more about Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

Vasta, J. D., Corona, C. R., Wilkinson, J., Zimprich, C. A., Hartnett, J. R., Ingold, M. R., … Robers, M. B. (2018). Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement. Cell Chemical Biology, 25(2), 206–214.e11.

Cloning, expression and purification of kinase domains of cacao PR-1 receptor-like kinases

  • Read more about Cloning, expression and purification of kinase domains of cacao PR-1 receptor-like kinases

Tosarini, T., Ramos, P., Profeta, G., Baroni, R., Massirer, K., Couñago, R., & Mondego, J. (2018). Cloning, expression and purification of kinase domains of cacao PR-1 receptor-like kinases. Protein Expression And Purification, 146, 78-84.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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