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A Chemical Biology Toolbox to Study Protein Methyltransferases and Epigenetic Signaling.

  • Read more about A Chemical Biology Toolbox to Study Protein Methyltransferases and Epigenetic Signaling.

Scheer, S., Ackloo, S., Medina, T. S., Schapira, M., Li, F., Ward, J. A., … Arrowsmith, C. H. (2019). A Chemical Biology Toolbox to Study Protein Methyltransferases and Epigenetic Signaling.. Nature communications, 10(1), 19.

UbiHub: A Data Hub for the Explorers of Ubiquitination Pathways

  • Read more about UbiHub: A Data Hub for the Explorers of Ubiquitination Pathways

Liu, L., Damerell, DR., Koukouflis, L., Tong, Y., Marsden, BD., Schapira, M. (2019). UbiHub: A Data Hub for the Explorers of Ubiquitination Pathways. Bioinformatics.

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

  • Read more about WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

Agajanian, M. J., Walker, M. P., Axtman, A. D., Ruela-de-Sousa, R. R., Serafin, D. S., Rabinowitz, A. D., … Major, M. B. (2019). WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell reports, 26(1), 79–93.e8.

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

  • Read more about An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

D'Ascenzio, M., Pugh, KM., Konietzny, R., Berridge, G., Tallant, C., Hashem, S., ... Brennan, PE. (2019). An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains. Angew Chemie International Edition, 58(4), 1007-1012.

ASPP Proteins Discriminate Between PP1 Catalytic Subunits Through Their SH3 Domain and the PP1 C-tail

  • Read more about ASPP Proteins Discriminate Between PP1 Catalytic Subunits Through Their SH3 Domain and the PP1 C-tail

Bertran, M. T., Mouilleron, S., Zhou, Y., Bajaj, R., Uliana, F., Kumar, G. S., … Tapon, N. (2019). ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Nature communications, 10(1), 771.

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

  • Read more about Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

Watts, E., Heidenreich, D., Tucker, E., Raab, M., Strebhardt, K., Chesler, L., … Hoelder, S. (2019). Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity. Journal of medicinal chemistry,62(5), 2618–2637.

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

  • Read more about SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

Asquith, C. R. M., Berger, B. T., Wan, J., Bennett, J. M., Capuzzi, S. J., Crona, D. J., ... Zuercher, W. J. (2019) SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). Journal of Medicinal Chemistry, 62, 2830-2836.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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