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Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function.

  • Read more about Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function.

Walker, B., Tempel, W., Zhu, H., Park, H., & Cochran, J. (2019). Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions To Perform a Similar Function. Biochemistry, 58(18), 2326-2338.

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.

  • Read more about A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.

Pfeiffer, M., Johansson, C., Krojer, T., Kavanagh, K. L., Oppermann, U., & Nidetzky, B. (2019). A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase. ACS catalysis, 9(4), 2962–2968.

Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus.

  • Read more about Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus.

Torell F, Eketjäll S, Idborg H, Jakobsson PJ, Gunnarsson I, Svenungsson E, Trygg J. Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus. (2019) Journal of Proteome Reseach. 18(3):1208-1217.

Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives.

  • Read more about Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives.

Idborg, H., Zandian, A., Sandberg, A. S., Nilsson, B., Elvin, K., Truedsson, L., … Jakobsson, P. J. (2019). Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives. Arthritis research & therapy, 21(1), 62. 

Divergent roles of prostacyclin and PGE2 in human tendinopathy.

  • Read more about Divergent roles of prostacyclin and PGE2 in human tendinopathy.

Bergqvist, F., Carr, A. J., Wheway, K., Watkins, B., Oppermann, U., Jakobsson, P. J., & Dakin, S. G. (2019). Divergent roles of prostacyclin and PGE2 in human tendinopathy. Arthritis research & therapy, 21(1), 74.

Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

  • Read more about Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

Rao, S., Gurbani, D., Du, G., Everley, R., Browne, C., Chaikuad, A., ... Gray, N. (2019). Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chemical Biology. S2451-9456(19)30076-5.

 

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.

  • Read more about Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.

Ebrahimi, A., Sevinç, K., Gürhan Sevinç, G., Cribbs, A. P., Philpott, M., Uyulur, F., … Önder, T. T. (2019). Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming. Nature chemical biology, 15(5), 519–528.

Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.

  • Read more about Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.

Paudel, P., Zhang, Q., Leung, C., Greenberg, H. C., Guo, Y., Chern, Y. H., … Tong, Y. (2019). Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X. Proceedings of the National Academy of Sciences of the United States of America, 116(15), 7288–7297. 

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.

  • Read more about The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.

Newman, J. A., Aitkenhead, H., Gavard, A. E., Rota, I. A., Handel, A. E., Hollander, G. A., & Gileadi, O. (2019). The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity. Journal of Biological Chemistry, 295(10), 2948–2958.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

  • Read more about The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Bushell, S. R., Pike, A. C. W., Falzone, M. E., Rorsman, N. J. G., Ta, C. M., Corey, R. A., … Carpenter, E. P. (2019). The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nature Communications, 10(1), 3956.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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