Discovery of a chemical probe for PRDM9.
Allali-Hassani, A., Szewczyk, M. M., Ivanochko, D., Organ, S. L., Bok, J., Ho, J., … Vedadi, M. (2019). Discovery of a chemical probe for PRDM9. Nature communications, 10(1), 5759.
Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.
Ni, X., Heidenreich, D., Christott, T., Bennett, J., Moustakim, M., Brennan, P., ... Chaikuad A. (2019). Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. ACS Medicinal Chemistry Letters, 10(12), 1661-1666.
Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension.
Chaikuad, A., Thangaratnarajah, C., von Delft, F., & Bullock, A. N. (2019). Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension. Scientific reports, 9(1), 18351.
Chemical probes for protein arginine methyltransferases.
Li, A., Li, F., Eram, M., Bolotokova, A., dela Seña, C., & Vedadi, M. (2019). Chemical probes for protein arginine methyltransferases. Methods.
Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells.
Sánchez-Duffhues, G., Williams, E., Benderitter, P., Orlova, V., van Wijhe, M., Garcia de Vinuesa, A., … Ten Dijke, P. (2019). Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. JBMR plus, 3(11), e10230.
The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma.
Ozyerli-Goknar, E., Sur-Erdem, I., Seker, F., Cingöz, A., Kayabolen, A., Kahya-Yesil, Z., … Bagci-Onder, T. (2019). The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma. Cell death & disease, 10(12), 894.
HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells.
Shukla, V., Halabelian, L., Balagere, S., Samaniego-Castruita, D., Feldman, D., Arrowsmith, C., ... Aravind, L. (2020). HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Molecular Cell, 77(2), 384-394.e4.
Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.
Profeta, G. S., Dos Reis, C. V., Santiago, A., Godoi, P., Fala, A. M., Wells, C. I., … Couñago, R. M. (2019). Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors. Scientific reports, 9(1), 16452.
Multiple direct interactions of TBP with the MYC oncoprotein.
Wei, Y., Resetca, D., Li, Z., Johansson-Åkhe, I., Ahlner, A., Helander, S., ... Sunnerhagen, M. (2019). Multiple direct interactions of TBP with the MYC oncoprotein. Nature Structural & Molecular Biology, 26(11), 1035-1043.
Design and analysis of the 4-anilino-quin(az)oline kinase inhibition profiles of GAK/SLK/STK10 using quantitative structure activity relationships.
Asquith, C., Laitinen, T., Bennett, J., Wells, C., Elkins, J., Zuercher, W., ... Poso, A. (2019). Design and Analysis of the 4‐Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure‐Activity Relationships. Chemmedchem, 15(1), 26-49.