Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery
Our aim is to identify and validate under-explored novel targets in auto-immune and inflammatory diseases. We do this by creating and profiling target-directed chemical and antibody probes in the highest quality patient-cell derived assays, providing biomarker and phenotypic read-outs in a more disease relevant context.
- Generate protein based research tools (e.g. structures, assays)
- Generate chemical and antibody probes
- Use patient-cell derived assays for target definition and validation
- Make all reagents and knowledge available through Open Source
- Significantly contribute to understanding of complex disease systems
- Promote drug discovery and development
- Fibrosis (of e.g. hand, lung and liver)
- Ankylosing spondylitis (AS)
- Fibrodysplasia ossificans progressiva (FOP, stone man syndrome)
- Systemic Lupus Erythematosus (SLE)
- Idiopathic myositis
- Systemic sclerosis (SSc)
- Sjogren´s syndrome (SS)