The promise and peril of chemical probes.
Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., … Zuercher, W. J. (2015). The promise and peril of chemical probes. Nature chemical biology, 11(8), 536–541.
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
Hammitzsch, A., Tallant, C., Fedorov, O., O’Mahony, A., Brennan, P. E., Hay, D. A., … Bowness, P. (2015). CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proceedings of the National Academy of Sciences of the United States of America, 112(34), 10768–10773.
Preclinical target validation using patient-derived cells
Edwards, A., Arrowsmith, C., Bountra, C., Bunnage, M., Feldmann, M., Knight, J., ... Young, L. (2015). Preclinical target validation using patient-derived cells. Nature Reviews Drug Discovery, 14(3), 149-150.