Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.

Kock, A., Larsson, K., Bergqvist, F., Eissler, N., Elfman, L., Raouf, J., … Kogner, P. (2018). Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth. EBioMedicine, 32, 84–92.

The Bone-Protecting Efficiency of Chinese Medicines Compared With Western Medicines in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Comparative Studies.

Cai, X., Chen, X. M., Xia, X., Bao, K., Wang, R. R., Peng, J. H., … Huang, Q. C. (2018). The Bone-Protecting Efficiency of Chinese Medicines Compared With Western Medicines in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Comparative Studies. Frontiers in pharmacology, 9, 914.

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.

Favalli, N., Biendl, S., Hartmann, M., Piazzi, J., Sladojevich, F., Gräslund, S., … Neri, D. (2018). A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition. ChemMedChem, 13(13), 1303–1307. 

Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies.

Fernandes-Cerqueira, C., Renard, N., Notarnicola, A., Wigren, E., Gräslund, S., Zubarev, R. A., … Lundström, S. L. (2018). Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies. Scientific reports, 8(1), 17958. doi:10.1038/s41598-018-36395-z.

AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation.

Hülsmann, J., Kravic, B., Weith, M., Gstaiger, M., Aebersold, R., Collins, B., Meyer, H. (2018). AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation. Molecular & Cellular Proteomics, 17(7), 1295-1307.

Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.

Rahm F, Viklund J, Trésaugues L, Ellermann M, Giese A, Ericsson U, ... Andersson M. (2018). Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design. Journal of Medicinal Chemistry, 61(6), 2533-2551.

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.

Moustakim, M., Riedel, K., Schuller, M., Gehring, A. P., Monteiro, O. P., Martin, S. P., … Brennan, P. E. (2018). Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorganic & medicinal chemistry, 26(11), 2965–2972.

Effects of FKBP12 and Type II BMP Receptors on Signal Transduction by ALK2 Activating Mutations Associated with Genetic Disorders.

Machiya A, Tsukamoto S, Ohte S, Kuratani M, Fujimoto M, Kumagai K, ... Katagiri T. (2018). Effects of FKBP12 and Type II BMP Receptors on Signal Transduction by ALK2 Activating Mutations Associated with Genetic Disorders. Bone, 111, 101-108.

Subscribe to 2018