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NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

  • Read more about NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

Marques, J. G., Gryder, B. E., Pavlovic, B., Chung, Y., Ngo, Q. A., Frommelt, F., Gstaiger, M., Song, Y., Benischke, K., Laubscher, D., Wachtel, M., Khan, J., & Schäfer, B. W. (2020). NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency. eLife, 9, e54993.

The human GID complex engages two independent modules for substrate recruitment.

  • Read more about The human GID complex engages two independent modules for substrate recruitment.

Mohamed, W. I., Park, S. L., Rabl, J., Leitner, A., Boehringer, D., Peter, M. (2021). The human GID complex engages two independent modules for substrate recruitment. EMBO reports, e52981. Advance online publication.

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

  • Read more about Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

Chen, Z., Zhang, J., Heilig, R., Sorrell, F., D’Angiolella, V., Fischer, R., ... Bullock, A. N. (2020). Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase. Cold Spring Harbor Laboratory

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.

  • Read more about Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.

Kidd, S., Fowler, E., Reinhardt, T., Compton, T., Mateu, N., Newman, H., ... Spring, D. (2020). Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chemical Science, 11(39), 10792-10801.

Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures.

  • Read more about Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures.

Baker, L., Aimon, A., Murray, J., Surgenor, A., Matassova, N., Roughley, S., ... Hubbard, R. (2020). Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures. Communications Chemistry, 3(1).

A lower X-gate in TASK channels traps inhibitors within the vestibule.

  • Read more about A lower X-gate in TASK channels traps inhibitors within the vestibule.

Rödström, K., Kiper, A. K., Zhang, W., Rinné, S., Pike, A., Goldstein, M., ... Carpenter, E. P. (2020). A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582(7812), 443–447.

Michelanglo: sculpting protein views on web pages without coding.

  • Read more about Michelanglo: sculpting protein views on web pages without coding.

Ferla, M. P., Pagnamenta, A. T., Damerell, D., Taylor, J. C., & Marsden, B. D. (2020). MichelaNglo: sculpting protein views on web pages without coding. Bioinformatics (Oxford, England), 36(10), 3268–3270.

Importance of Quantifying Drug-Target Engagement in Cells.

  • Read more about Importance of Quantifying Drug-Target Engagement in Cells.

Stefaniak, J., & Huber, K. (2020). Importance of Quantifying Drug-Target Engagement in Cells. ACS medicinal chemistry letters, 11(4), 403–406.

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.

  • Read more about Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.

Fortin, J., Tian, R., Zarrabi, I., Hill, G., Williams, E., Sanchez-Duffhues, G., ... Mak, T. W. (2020). Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas. Cancer cell, 37(3), 308–323.e12.

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.

  • Read more about Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.

Ensan, D., Smil, D., Zepeda-Velázquez, C. A., Panagopoulos, D., Wong, J. F., Williams, E. P., ... Al-Awar, R. (2020). Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of medicinal chemistry, 63(9), 4978–4996.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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