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ULTRA-DD

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Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.

  • Read more about Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.

Abdul Azeez, K. R., Chatterjee, S., Yu, C., Golub, T. R., Sobott, F., & Elkins, J. M. (2019). Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Nature communications, 10(1), 3166.

2-Amino-2, 3-Dihydro-1H-Indene-5-Carboxamide-Based Discoidin Domain Receptors 1 (DDR1) Inhibitors: Design, Synthesis, and In Vivo Anti-pancreatic Cancer Efficacy.

  • Read more about 2-Amino-2, 3-Dihydro-1H-Indene-5-Carboxamide-Based Discoidin Domain Receptors 1 (DDR1) Inhibitors: Design, Synthesis, and In Vivo Anti-pancreatic Cancer Efficacy.

Zhu, D., Huang, H., Pinkas, D. M., Luo, J., Ganguly, D., Fox, A. E., … Lu, X. (2019). 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. Journal of medicinal chemistry, 62(16), 7431–7444.

Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).

  • Read more about Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).

Asquith, C., Treiber, D., & Zuercher, W. (2019). Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Bioorganic & Medicinal Chemistry Letters, 29(14), 1727-1731.

Identification and characterization of the first fragment hits for SETDB1 Tudor domain.

  • Read more about Identification and characterization of the first fragment hits for SETDB1 Tudor domain.

Mader, P., Mendoza-Sanchez, R., Iqbal, A., Dong, A., Dobrovetsky, E., Corless, V., ... Arrowsmith, C. (2019). Identification and characterization of the first fragment hits for SETDB1 Tudor domain. Bioorganic & Medicinal Chemistry, 27(17), 3866-3878.

Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines.

  • Read more about Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines.

Asquith, C., Fleck, N., Torrice, C., Crona, D., Grundner, C., & Zuercher, W. (2019). Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines. Bioorganic & Medicinal Chemistry Letters, 29(18), 2695-2699.

Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor.

  • Read more about Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor.

Zhang, C., Creech, K. L., Zuercher, W. J., & Willson, T. M. (2019). Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor. Scientific reports, 9(1), 9982.

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

  • Read more about Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Böttcher, J., Dilworth, D., Reiser, U., Neumüller, R., Schleicher, M., Petronczki, M., ... McConnell D. (2019). Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature Chemical Biology, 15(8), 822-829.

Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1.

  • Read more about Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1.

Chen, S., Zhang, W., Min, J., & Liu, K. (2019). Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1. Methods.

High-Throughput Purification of Protein Kinases from Escherichia coli and Insect Cells.

  • Read more about High-Throughput Purification of Protein Kinases from Escherichia coli and Insect Cells.

Mathea, S., Salah, E., & Knapp, S. (2019). High-Throughput Purification of Protein Kinases from Escherichia coli and Insect Cells. Methods In Molecular Biology, 191-202.

Target 2035: probing the human proteome.

  • Read more about Target 2035: probing the human proteome.

Carter, A., Kraemer, O., Zwick, M., Mueller-Fahrnow, A., Arrowsmith, C., & Edwards, A. (2019). Target 2035: probing the human proteome. Drug Discovery Today, 24(11), 2111-2115.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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