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The dynamic conformational landscape of the protein methyltransferase SETD8.

  • Read more about The dynamic conformational landscape of the protein methyltransferase SETD8.

Chen, S., Wiewiora, R. P., Meng, F., Babault, N., Ma, A., Yu, W., … Luo, M. (2019). The dynamic conformational landscape of the protein methyltransferase SETD8. eLife, 8, e45403.

The promise and peril of chemical probes.

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Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., … Zuercher, W. J. (2015). The promise and peril of chemical probes. Nature chemical biology, 11(8), 536–541.

TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma.

  • Read more about TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma.

Nakayama, K., Szewczyk, M. M., Dela Sena, C., Wu, H., Dong, A., Zeng, H., … Brown, P. J. (2018). TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget, 9(26), 18480–18493.

Donated Chemical Probes for Open Science

  • Read more about Donated Chemical Probes for Open Science

Müller, S., Ackloo, S., Arrowsmith, C. H., Bauser, M., Baryza, J. L., Blagg, J., … Mueller-Fahrnow, A. (2018). Donated chemical probes for open science. eLife, 7, e34311.

Progress towards a public chemogenomic set for protein kinases and a call for contributions

  • Read more about Progress towards a public chemogenomic set for protein kinases and a call for contributions

Drewry, D. H., Wells, C. I., Andrews, D. M., Angell, R., Al-Ali, H., Axtman, A. D., … Willson, T. M. (2017). Progress towards a public chemogenomic set for protein kinases and a call for contributions. PLoS ONE, 12(8), e0181585.

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The ULTRA-DD project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° [115766], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. This website reflects only the author’s views and neither IMI nor the European Commission is liable for any use that may be made of the information contained therein.
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