WP1: Selection of targets and high priority protein families (Julian Knight, University of Oxford)
WP2: Protein expression and purification (Nicola Burgess-Brown, University of Oxford & Susanne Gräslund, Karolinska Institutet)
WP3: Biochemical, biophysical and cellular assays (Gillian Farnie and Kilian Huber, University of Oxford)
WP4: Protein and protein complex structure determination (Liz Carpenter and Frank von Delft, University of Oxford & Ruedi Aebersold and Mathias Gstaiger, ETH)
WP5: Chemical hit identification and chemical probe generation (Paul Brennan & Stefan Knapp, University of Oxford)
WP6: Cell and tissue phenotypic assays linked to inflammatory mechanisms of disease (Paul Bowness, Marc Feldmann and Jagdeep Nanchahal, University of Oxford & Per-Johan Jakobsson, Lars Klareskog and Ingrid Lundberg, Karolinska Institutet)
WP7: Data and Reagent Dissemination (Brian Marsden, University of Oxford)
WP8: Amplifying ULTRA-DD impact through a large collaborative network (Wenhwa Lee, University of Oxford)
WP9: Project management and translation of results (Aled Edwards, University of Toronto; Nils Ostermann, Novartis & Michael Sundström, Karolinska)